Burglars took a large haul of cigarettes from the Co-op in Station Road, Rudgwick, early on Saturday morning.
Police were called to reports of a break-in at 5.10am on Saturday April 13.
A large quantity of cigarettes was taken from behind the till.
Police say two people, wearing hooded tops with their hoods up, were seen running away and getting into a car.
Anyone with information is asked to call police on 101, quoting serial 285 of 13/4 or alternatively contact the independent charity Crimestoppers on 0800 555 111.